High incidence of degenerative skeletal tissue disorders in a progressively aging human population make tissue engineering of cartilage and bone a focus of extensive research. Bone and joint disorders are the most common disease in Europe: more than 100 million European citizens suffer from arthritis and 19 million people have osteoporosis (one of three women and one of eight men are affected).
This project is designed to supplement the previous EuroNanoMed project aimed to develop an innovative strategy for targeting bone and cartilage regeneration. More specifically the proposal seeks to set up an international multidisciplinary team of young scientists and engineers representing both academia and industry partners that will strongly contribute to the design of a novel type of implant, which can strongly promote tissue regeneration combining high performance materials, advanced nanotechnology and living cells.
Network for Development of Soft Nanofibrous Construct for Cellular Therapy of Degenerative Skeletal Disorders
The major objective of this project is to bring together the expertise of academia and industry partners for the development of an innovative complementary strategy for targeting bone and cartilage regeneration. They will be involved in the design of an advanced tissue engineering construct comprising of bioinspired gel with unique biomechanical properties containing oriented nanofibres and bioactive molecules resembling the natural spatiotemporal cues of the extracellular matrix. It is further combined with human mesenchymal stem cells (hMSC) differentiating into osteogenic or chondrogenic lineages.
This challenging approach requires collaboration of researchers from different disciplines such as materials science, chemistry, nanoengineering and cell biology. The involvement of both academia and industrial partners will assure the bidirectional transfer of knowledge and shall result in the creation of commercial product(s) expecting medical application.
The proposed multidisciplinary approach aims to gain radical innovation in the strategy for treatment of the skeletal disorders with a strong impact in the long term for a variety of fields such as nanobioengineering and regenerative medicine.